MLB Home Run Predictions Today: Best HR Prop Bets for Wednesday, Sept. 23

It’s “Wednesday Wallop Watch,” with three bats ready to send some souvenirs into the seats. William Contreras gets Aaron Nola, whom he’s hitting .344 against in his career. Bryan Reynolds faces Matthew Liberatore, who’s allowed 20 homers to right-handed bats this season. Ben Rice draws Ian Seymour with two homers in just six career at-bats against him.

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Contreras, Reynolds and Rice have the history, splits, and pitching matchups to make Wednesday a busy night in the bleachers.

All odds are from DraftKings Sportsbook and are subject to change. DraftKings does not sponsor this content.

  • Best MLB First-Inning Predictions (NRFI/YRFI) for Wednesday, Sept. 23

Best Home Run Props Today

William Contreras Home Run Bet (+610)

Contreras is heating up, crushing four homers since Sept. 9 to reach 18 on the season. He also knows Aaron Nola well, going 11-for-32 with two doubles and a homer against him. Nola has been vulnerable to the long ball, surrendering 34 homers this season, including 14 to right-handed hitters.

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Bryan Reynolds Home Run Bet (+TBD)

Reynolds has 17 homers this season and gets a favorable matchup Wednesday against Matthew Liberatore. Reynolds is 6-for-18 against the lefty with two doubles and a homer. Liberatore has surrendered 27 bombs this season, including 20 to right-handed hitters. The switch-hitting Reynolds will bat from the right side, where the matchup sets up nicely.

Ben Rice Home Run Bet (+TBD)

Rice is sitting one homer shy of 40, and Wednesday gives him a great chance to reach the milestone. He’s already gone deep four times in September and is 3-for-6 against Ian Seymour with two homers. Seymour has surrendered five bombs in three starts this month and 25 overall. Rice has already shown he can get to him.

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2026 MLB HR Leaders

  • DH Kyle Schwarber, Philadelphia Phillies (45)
  • CF Pete Crow-Armstrong, Chicago Cubs (45)
  • 3B Junior Caminero, Tampa Bay Rays (41)
  • DH Yordan Alvarez, Houston Astros (40)
  • 1B Matt Olson, Atlanta Braves (40)
  • 1B Pete Alonso, Baltimore Orioles (40)

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This story was originally published September 23, 2026 at 4:30 AM.

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