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Week 2 of the 2026 NFL regular season is here.
The second week of the 2026 NFL regular season begins on Thursday evening. The Buffalo Bills will be hosting the Detroit Lions in their first game at their new stadium. It should be a fun one in Buffalo.
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The Bills enter the 2026 NFL regular season with high expectations. Josh Allen and Co. have a Super Bowl on their mind. The Bills, who have had some heartbreaking playoff losses in recent years, are hoping to go deep this winter.
ESPN’s computer model, the Football Power Index, seems to think that the 49ers are capable of doing just that.
ESPN’s computer model, the Football Power Index, has the Bills as the No. 2 favorite to win the Super Bowl right now. The Bills are only trailing the San Francisco 49ers following Week 1. The 49ers are coming off a decisive Week 1 victory against the Rams in Australia.
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Football Power Index’s 10 Super Bowl favorites
ESPN’s computer model ranked the 10 Super Bowl frontrunners heading into Week 2 on Thursday night:
- San Francisco 49ers
- Buffalo Bills
- Baltimore Ravens
- Kansas City Chiefs
- Jacksonville Jaguars
- Chicago Bears
- Seattle Seahawks
- Los Angeles Rams
- Cincinnati Bengals
- Philadelphia Eagles
The Rams are the only team in the top 10 to lose their first game of the season.
“The Football Power Index (FPI) is a measure of team strength that is meant to be the best predictor of a team’s performance going forward for the rest of the season. FPI represents how many points above or below average a team is. Projected results are based on 10,000 simulations of the rest of the season using FPI, results to date, and the remaining schedule. Ratings and projections update daily,” ESPN writes.
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Kickoff on Thursday night is set for 8:15 p.m. E.T.
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This story was originally published September 17, 2026 at 4:00 PM.