Final Injury Report for Eagles-Jaguars: Will Saquon Barkley, DeVonta Smith Play?

The Philadelphia Eagles are in London Sunday morning as they face off against the Jacksonville Jaguars in a Week 5 interconference showdown.

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Philadelphia enters Sunday’s game with a 2-2 record after losing at home to the Los Angeles Rams in Week 4.

In their loss to the Rams, Jalen Hurts led the way for the Eagles as he recorded 93 passing yards and two passing touchdowns while Darius Cooper added 33 receiving yards and two receiving touchdowns.

The Eagles will try to bounce back Sunday as they face off against the Jaguars in a tough international matchup.

Jacksonville enters Sunday’s contest with a 3-1 record after defeating the Cincinnati Bengals on the road in Week 4.

Trevor Lawrence led the way for the Jaguars in their victory over the Bengals as he ended the game with 227 passing yards and one passing touchdown while Brenton Strange recorded 95 receiving yards.

While both teams are looking to pick up a victory in Sunday morning’s matchup, each may be without multiple key players due to injuries.

Eagles Injury Report: Will Saquon Barkley, DeVonta Smith Play?

The Eagles have six players listed on their injury report, including running back Saquon Barkley and wide receiver DeVonta Smith.

Philadelphia has ruled out Barkley due to a right hamstring injury that he suffered in Week 4 as he will miss his first game of the season.

Friday’s Injury Report#PHIvsJAXpic.twitter.com/DY2iRiLFmu

— Philadelphia Eagles (@Eagles) October 9, 2026

With Barkley sidelined, along with Tank Bigsby who was put on injured reserve earlier this week, Will Shipley and Dameon Pierce are both expected to have increased roles.

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The Eagles have also ruled out Smith as he will miss his second consecutive contest with a hamstring injury.

With Smith sidelined once again, Makai Lemon and Cooper could both be in line for increased roles.

Wide receiver Hollywood Brown (ankle), safety Marcus Epps (groin) and center Drew Kendall (knee) have also all been ruled out while outside linebacker Jonathan Greenard has been listed as questionable with an ankle injury.

The good news for the Eagles is that Hurts is expected to play after he was added to the injury report Friday with a calf injury.

Jaguars Injury Report

The Jaguars have two players listed on their injury report, including newly signed cornerback Jaylon Jones.

Jacksonville has ruled out Jones due to a hamstring injury as he will not make his season debut Sunday after being signed to the 53-man roster earlier this week.

#PHIvsJAX Status Report pic.twitter.com/wMR03uK6RP

— Jacksonville Jaguars (@Jaguars) October 9, 2026

The Jaguars have listed safety Eric Murray as doubtful and he is expected to be sidelined due to a concussion.

Fans can catch Sunday morning’s matchup between the Eagles and Jaguars from Tottenham Hotspur Stadium in London at 9:30 a.m. ET on NFL Network.

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This story was originally published October 11, 2026 at 3:30 AM.

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