The Pittsburgh Steelers will play host for a Week 5 matchup with the Colts, and fantasy football managers have several decisions to make before kickoff. With injuries affecting Pittsburgh’s receiving corps and key players carving out larger roles in the offense, this week’s matchup presents opportunities to capitalize on favorable situations while avoiding potential disappointments.
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Roman Wilson could be in line for a bigger role, while Jaylen Warren continues to establish himself as a reliable fantasy option. However, not every Steeler is worth starting this week. Here’s a look at which Pittsburgh players to start or sit in fantasy football against Indianapolis.
START: Roman Wilson
With Michael Pittman Jr. out,, Wilson is heating up, and he has looked sharp against man coverage. The Colts play man coverage frequently and rank 24th in average points allowed to wide receivers per game.
This could be a breakout game for Wilson, as he has an opportunity to seize the WR2 role in Pittsburgh.
SIT: Darnell Washington
Washington will likely see plenty of playing time on Sunday, but much of his work will come as a blocker in the running game. He should still contribute as a pass catcher, just not as heavily as he might in other weeks.
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Washington can be hit or miss in a week-to-week fantasy league. He has made plenty of big plays for the Steelers, but his expected role against the Colts makes him a risky option this week.
START: Jaylen Warren
Warren will likely shoulder the load once again, and that could remain the case for the foreseeable future. He has delivered in both the passing game and the rushing attack, giving fantasy managers multiple ways to benefit from his production.
Until the Warren train slows down, keep starting him.
START: Steelers D/ST
Even after allowing 27 points in each of the past two weeks, the Steelers’ defense and special teams have still produced positive fantasy scores. Pittsburgh has routinely forced turnovers and generated sacks, giving this unit a solid fantasy floor.
The Steelers have a particularly appealing opportunity against Daniel Jones, who has thrown six interceptions against Pittsburgh in three career games. That history makes the Steelers’ D/ST an intriguing fantasy option in Week 5.
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This story was originally published October 11, 2026 at 6:00 AM.
