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The Arizona Cardinals are on the road Sunday evening as they travel to take on the Los Angeles Chargers in an interconference matchup during Week 1 of the 2026 NFL season.
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Arizona enters Sunday’s game looking to start the season off strong by grabbing a key victory on the road as the Cardinals begin a new chapter under head coach Mike LaFleur after firing Jonathan Gannon following their disappointing season last year.
Los Angeles enters Sunday’s contest looking to grab a victory at home as the Chargers try to compete for the AFC West title and make a deep playoff run.
While both teams are looking to pick up a victory in Sunday evening’s matchup, each may be without multiple key players due to injuries.
Cardinals Injury Report: Will Jeremiyah Love Play?
The Cardinals have four players listed on their injury report, including rookie running back Jeremiyah Love.
Arizona has listed Love as questionable due to an ankle injury that limited him in practice throughout the week, though the No. 3 overall pick in the 2026 draft is expected to make his NFL regular season debut Sunday.
Jeremiyah Love is questionable for Sunday’s game against the Chargers.
And the rest of Friday’s injury report… pic.twitter.com/4k0f5s3Xjr
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— Josh Weinfuss (@joshweinfuss) September 11, 2026
The Cardinals have ruled out cornerback Garrett Williams (Achilles), safety Dadrion Taylor-Demerson (ribs) and offensive lineman Isaiah Adams (knee) as they will all miss Arizona’s season opener.
Chargers Injury Report: Will Khalil Mack Play?
The Chargers have two players listed on their injury report, though outside linebacker Khalil Mack is not one of them.
Of course, Mack did not practice Wednesday due to rest but after practicing fully Thursday and Friday, the veteran pass rusher is off the injury report and will play against the Cardinals.
game status for week 1 vs. AZ
QUESTIONABLE — Tuli Tuipulotu
OUT — Deane Leonard
— Los Angeles Chargers (@chargers) September 11, 2026
Los Angeles has ruled out defensive back Deane Leonard due to an abdomen injury as he will miss the Chargers’ season opener.
The Chargers have listed outside linebacker Tuli Tuipulotu as questionable due to a hip injury and he is in danger of missing Sunday’s game.
Fans can catch Sunday evening’s matchup between the Cardinals and Chargers from SoFi Stadium at 4:25 p.m. ET on CBS in both teams’ home markets and select other locations across the country. Check local listings for games available in your area.
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This story was originally published September 13, 2026 at 8:30 AM.